LOEWS HOTEL, CHICAGO  |  SEPTEMBER 6-8, 2024

It’s an honor to host you in Chicago, a city renowned for its architectural ingenuity. Just as architects here have redefined skylines with bold, functional designs, you are architects in your own right — revolutionizing neurosurgery with cutting-edge, incisionless techniques with focused ultrasound.

The year 2024 is a pivotal one for us here at Insightec. Not only does it mark our 25th year of commitment toward this paradigm shift in healthcare, but we’ve also launched our flagship platform, Exablate Prime, secured reimbursement for millions of US military members and their families, and are on the brink of reaching the impressive milestone of 20,000 commercial cases. And as important as these achievements are for us today, it’s the future where our collective vision will be realized, improving lives for millions around the world. That will be our legacy.

In our time together, I encourage you to exchange ideas, share insights, and collaborate on the challenges and opportunities that lie ahead. The future is shaped by those who dare to innovate, and I’m excited to see what we can achieve together.

Welcome, innovators. Let’s make the future happen.

— Maurice R. Ferré M.D., CEO and Chairman

Focus Forward Steering Committee Members

NEUROSURGERY

Rees Cosgrove, M.D.
Rees Cosgrove, M.D.

Committee Chair

Rees Cosgrove, M.D. // Director of Epilepsy and Functional Neurosurgery; Brigham and Women’s Hospital

Dr. Cosgrove is an internationally acclaimed expert in stereotactic and functional neurosurgery with over 30 years of experience in the field. He specializes in the surgical treatment of epilepsy and has performed over 1,200 operations for patients with intractable seizures. He also specializes in the surgical treatment of Parkinson’s disease, tremor, dystonia, and other movement disorders. He has performed over 600 operations in patients with intractable movement disorders including thalamotomy, pallidotomy, deep brain stimulation, and other neuromodulation procedures. Dr. Cosgrove was an early adopter of MRgFUS, and he has performed over 400 procedures and has been involved in many of the early clinical trials. He is a past president of the American Society of Functional and Stereotactic Neurosurgery and is an executive member of the World Society of Functional and Stereotactic Neurosurgery.

Dr. Ponce is the chief of stereotactic and functional neurosurgery and the program director of the neurosurgery residency program. He specializes in the neurosurgical treatment of movement disorders using modalities such as deep brain stimulation and focused ultrasound.

Francisco A. Ponce, M.D.
Francisco A. Ponce, M.D.
Francisco A. Ponce, M.D. // Associate Professor in the Department of Neurosurgery; Barrow Neurological Institute

Dr. Ponce is the chief of stereotactic and functional neurosurgery and the program director of the neurosurgery residency program. He specializes in the neurosurgical treatment of movement disorders using modalities such as deep brain stimulation and focused ultrasound.

Ahmed Raslan, M.D.
Ahmed Raslan, M.D.
Ahmed Raslan, M.D. // Vice Chair for Clinical Affairs,
Chief of the Division of Functional Neurosurgery and Professor of Neurological Surgery; Oregon Health & Science University

Dr. Raslan specializes in brain and spinal cord cancer, chronic pain, epilepsy, focused ultrasound, neuro-oncology, neuroscience, Parkinson’s, and movement disorders. He also treats patients who have chronic pain, such as facial and spinal pain, and pain from cancer.

Some of the surgeries he performs include brain mapping and awake craniotomy for epilepsy and brain tumors, focused ultrasound for essential tremor and Parkinson’s disease, and deep brain stimulation for epilepsy and movement disorders. Dr. Raslan completed his residency at Oregon Health & Science University and continued with his fellowship in stereotactic and functional neurosurgery. He went on to have an additional fellowship in Neurological Surgery at the University of British Columbia.

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NEUROLOGY

Daniel Roque, M.D.
Daniel Roque, M.D.
Daniel Roque, M.D. // Director of Movement Disorders Neuromodulation Program; University of North Carolina

Dr. Roque is a board-certified neurologist and movement disorders specialist with specific expertise diagnosing and treating multiple tremor syndromes. His clinical and research focus is on the improvement of tremors through both traditional and innovative methods, seeking out quality-of-life initiatives for patients with movement disorders. He serves on multiple regional and national forums aimed at improving outcomes for tremor management.

Justin Martello, M.D.
Justin Martello, M.D.
Justin Martello, M.D. // Parkinson’s and Movement Disorders Director & Focused Ultrasound Director; ChristianaCare Neurology Specialists

Dr. Martello is a movement disorders trained neurologist from University of Maryland and currently is the Movement Disorders and Focused Ultrasound Director at ChristianaCare in Delaware. He has recently started performing MR-guided focused ultrasound for tremors with the new Exablate Prime system. He has published in the Parkinson’s disease guidelines and quality measures space, and is active in the American Academy of Neurology working committees.

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RADIOLOGY

Lubdha Shah, M.D.
Lubdha Shah, M.D.
Lubdha Shah, M.D. // Professor of Neuroradiology;
University of Utah Hospital

Dr. Shah has expertise in advanced brain and spine imaging, particularly functional MRI and diffusion imaging. She collaborates with neurosurgery in the MR-guided focused ultrasound clinical treatments and research. The University of Utah focused ultrasound program has been successfully treating patients since February 2019 and is close to completing 200 cases.

Jody Tanabe, M.D.
Jody Tanabe, M.D.
Jody Tanabe, M.D. // Professor and Chief of Neuroradiology;
University of Colorado Anschutz Medical

Dr. Tanabe specializes in advanced imaging and neuromodulation for neuropsychiatric disorders and movement disorders. She is a founding member of the Colorado Neuromodulation of Addiction (CONA) Lab at University of Colorado. She is president-elect of the American Society of Functional Neuroradiology and serves on the ASNR Study Group for Transcranial Focused Ultrasound.

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Empowerment Workshop

Friday, September 6

Empowerment Workshop: Mastering the Learning Curve

4:30 p.m. – 6:00 p.m.
This is a tips and tricks session for building confidence in system functionality, laying the groundwork for a quick program start, and accelerating your treatment proficiency. Attendees will explore the core tenants of an MR-guided focused ultrasound program and the building blocks needed to accelerate their way through the procedural learning curve and achieve rapid program expansion.
Building a Focused Ultrasound Service Line
Moderator:
JJ Desai, M.D.
Insightec Chief Strategy
& Innovation Officer


Panelists:
Ahmed M. Raslan, M.D.
Nandan Lad, M.D., Ph.D.
Erika Schouten
Focused Ultrasound as a New Service Line
Moderator:
Peter Herrera
Insightec VP of Clinical Sales

Panelists:
Stephen Harward II, M.D., Ph.D.
Justin Martello, M.D.
Activating Inside Your Health Network
Moderator:
Katie Davis
Insightec Associate Director of
Market Development


Panelists:
Mark Hoeprich, M.D.
Albert Fenoy, M.D.
Kristen Ambrosio, N.P.
Embracing Market Development
Navigating the Clinical Learning Curve
Moderator:
Neha Dhawan
Insightec Director of Clinical Applications

Panelists:
Rees Cosgrove, M.D.
DJ Vile, Ph.D
Advancing the Application of Exablate
Moderator:
David Tilden
Insightec Manager of Clinical Applications

Panelists:
Ahmed M. Raslan, M.D.
Stephen Harward II, M.D., Ph.D.
Justin Martello, M.D.
Learning Curve Case Studies
Moderator:
Neha Dhawan
Insightec Director of Clinical Applications

Panelists:
Bhavya R. Shah, M.D.
Zachary T. Levine, M.D.
Ahmed M. Raslan, M.D.
Case Day Workflow Efficiencies
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Agenda

Saturday, September 7

7:00 a.m. – 5:00 p.m. Innovation stations open
7:00 a.m. – 8:00 a.m. Breakfast
8:00 a.m. – 8:30 a.m. Opening remarks

Welcome to Focus Forward 2024

Opening — Maurice R. Ferré, M.D.,
Insightec CEO and Chairman of the Board

Welcome to Focus Forward 2024
Foundations of Change:

Creating the Future of Healthcare
Keynote Address — Omar Ishrak, Ph.D.,
Medtronic – Former CEO and Former Chairman of the Board

Evolution of Focused Ultrasound

8:30 a.m. – 9:00 a.m.
Moderator:
Rees Cosgrove, M.D.

Panelists:
Jeff Elias, M.D.
Francisco Ponce, M.D.
Prof. Günther Deuschl, M.D.
  • Progress since the first regulatory approval
  • Focused ultrasound as frontline therapy
  • The continued unmet need

Case Day Best Practices

9:00 a.m. – 12:00 p.m.
From frame on to frame off, discuss the techniques, nuances, and art of an effective, efficient, and safe focused ultrasound treatment.
Learn the best practices derived from experience and explore the modern mindset.
Targeting
Moderator:
Lubdha Shah, M.D.

Panelists:
Bhavya R. Shah, M.D.
Charles Munyon, M.D.
  • Tractography tools
  • Targeting approaches to avoid complications
  • Moving around the VIM – ET vs TDPD,
    targeting specific tremor aspects
    Hot Topic Debate:
    Use of advanced MR imaging in targeting
Sonication Parameters
Moderator:
Francisco Ponce, M.D.

Panelists:
Zachary Levine, M.D.
Ahmed Raslan, M.D., Ph.D.
Drew Kern, M.D., M.S.
  • The trend of reducing the number of sonications
  • Low SDR treatments
  • Nuances of temperature in lesion creation
  • Lesion characteristics: what is the ideal size?
  • When to stop
  • Expectations of complications on the table
Patient Selection & Testing
Moderator:
Daniel Roque, M.D.

Panelists:
Padraig O’Suilleabhain, M.D.
Leonard Verhagen, M.D., Ph.D.
  • Pre-treatment evaluation
  • On-table evaluation
  • Post-treatment evaluation and setting recovery expectations
  • Multi-functional patient care team
  • Fun cases and tests
Case Series / Q&A
Moderator:
Rees Cosgrove, M.D.

Panelists:
Jeff Elias, M.D.
Peter Konrad, M.D., Ph.D.
  • Challenging and interesting cases
  • Retreatments
  • Stump the expert
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Building Programmatic Success

1:00 p.m. – 2:45 p.m.
Discuss resources and systems to build a highly functioning, thriving, and financially beneficial focused ultrasound program in a well-developed market. Outside of the procedure itself, how do you build and grow a successful focused ultrasound program and incorporate it into a busy movement disorder practice? From building patient volumes to getting paid, this session will cover the less clinical topics that still need to be well executed in order to have a thriving MR-guided focused ultrasound program.
Reimbursement & Payment
Moderator:
Ahmed Raslan, M.D.

Panelists:
Daniel Roque, M.D.
Zachary Levine, M.D.
Erika Schouten
  • Reimbursement update — JJ Desai, M.D.
    Insightec Chief Strategy & Innovation Officer
  • Revenue and payment
Market Development
Moderator:
Justin Martello, M.D.

Panelists:
Stephen Harward II, M.D., Ph.D.
Francisco Ponce, M.D.
Kristen Ambrosio, N.P.
  • Marketing
  • Using patient data tools
  • Referral building
Capacity Expansion
Moderator:
Jody Tanabe, M.D.

Panelists:
Nandan Lad, M.D., Ph.D.
Steven Ojemann, M.D.
  • Competing for MRI time
  • Training the users of tomorrow
Moderator:
Jody Tanabe, M.D.

Panelists:
Rees Cosgrove, M.D.
Justin Martello, M.D.
Timothy Kaufmann, M.D.
Hot Topic Debate:
The role of the non (functional) neurosurgeon in focused ultrasound procedures
2:45 p.m. – 3:00 p.m. Break
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Technology & Product Advancements – Current Indications

3:00 p.m. – 5:00 p.m.
What are the clinotechnical advancements, newest indications, and next generation platforms that are leading the way in the future of approved MR-guided focused ultrasound procedures? Discuss and demonstrate the latest advancements and newest indications, including Exablate Prime, second-side data, survey results, and new imaging tactics.
Exablate Prime
Moderator:
Ahmed Raslan, M.D.

Panelists:
Daniel Cleary, M.D., Ph.D.
Mark Hoeprich, M.D.
Lior Lev Tov, M.D.
Omri Funaro
Insightec Senior Clinical
Product Manager
  • Prime demo
  • Imaging improvements
  • Efficiency and case time
  • Q&A
Second Side
Moderator:
Francisco Ponce, M.D.

Panelists:
Michael Kaplitt, M.D., Ph.D.
Charles Munyon, M.D.
Stephen Harward II, M.D., Ph.D.
Chandan Reddy, M.D.
  • One-year data
  • First side vs second side treatments
  • Workflow and patient selection
  • Lessons learned
Imaging
Moderator:
Lubdah Shah, M.D.

Panelists:
Daniel Cleary, M.D., Ph.D.
Lain Hermes González Quarante, M.D.
  • Optimizing your imaging
  • 3T head coil
5:30 p.m. — 8:00 p.m. Reception
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Sunday, September 8

8:00 a.m. – 11:30 p.m. Innovation stations open
8:00 a.m. – 9:00 a.m. Breakfast

Technology & Clinical Advancements: Exploratory

9:00 a.m. – 11:15 a.m.
What is the future of MR-guided focused ultrasound, both with the high frequency and low frequency platforms? Hear highlights of some exciting research being done in the field of neuro focused ultrasound.
Parkinson’s Disease
Moderator:
Rees Cosgrove, M.D.

Panelists:
Marta Del Alamo, M.D.
Lain Hermes González Quarante, M.D.
Prof. Günther Deuschl, M.D.
Michael Kaplitt, M.D., Ph.D.
  • PTT case examples
  • STN: The European experience
  • Target selection in focused ultrasound for PD
Research Toward Expanded Indications – High Frequency
Moderator:
Rees Cosgrove, M.D.
Speakers:
  • Pain – Shayan Moosa, M.D.
  • Multi-site lesioning – Lior Lev Tov, M.D.
Research Toward Expanded Indications – Low Frequency
Moderator:
Jody Tanabe, M.D.
Speakers:
  • Addiction – Peter Konrad, M.D.
  • Drug delivery / tumor – DJ Vile, Ph.D.
Ask Insightec
Moderator:
Jody Tanabe, M.D.

Panelists:
Maurice R. Ferré M.D.
CEO and Chairman
Eyal Zadicario, Ph.D.
Insightec Chief Operating Officer and
General Manager

JJ Desai, M.D.
Insightec Chief Strategy & Innovation Officer
  • Insightec R&D
  • Insightec Leadership
11:15 a.m. – 11:30 a.m. Meeting Close
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